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By Kenneth P. Murphy

Univ. of Iowa, Iowa urban. deals protein and biophysical chemists a source for gaining how to comprehend and symbolize the root for the steadiness of the biologically lively local states of proteins. information significant cutting edge recommendations in use and emphasizes the idea at the back of each one experimental strategy.

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N. (1985) The stabilization of proteins by osmolytes. Biophys. J. 47, 411–414. 21. Lee, J. C. and Lee, L. -Y. (1981) Preferential solvent interactions between proteins and polyethylene glycols. J. Biol. Chem. 256, 625–631. 22. Lee, L. -Y. and Lee, J. C. (1987) Thermal stability of proteins in the presence of poly(ethylene glycols). Biochemistry 26, 7813–7819. 23. Timasheff, S. N. (1993) The control of protein stability and association by weak interactions with water: how do solvents affect these processes?

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This estimation must be done in a way that avoids the subtraction of large numbers inherent to separate calculations of internal interactions and hydration. In our calculations, we decided to make the coefficients in Eq. 4 a function of the interior packing in the protein. Thus far, the best agreement with the experimental results have been obtained when the the coefficients are scaled in terms of the average number of nonbonded atoms that are within 3 Å of solvent-buried atoms within the protein.

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