By Alexander T. Florence, David Attwood
A longtime textbook that gives you with complete insurance of the physicochemical rules necessary to the fashionable pharmacist and pharmaceutical scientist. This 6th version has a wide chemical and physicochemical base and covers each element of drug homes from the layout of dosage varieties to their supply via all routes to websites of motion within the physique. Now with extra scientific examples, new questions and additional case stories.
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Extra info for Physicochemical Principles of Pharmacy
4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. N. Pilpel. Endeavour (NS) 6, 1983 (1982) J. W. Mullin. Crystallization, 2nd Edition, Butterworths, London, 1972 A. S. Michaels and A. R. Colville. J. phys. , 64, 13 (1960) E. Shefter and T. J. pharm. , 52,781 (1963) J. H. Chapman, et al. J. Pharm. , 20,418 (1968) M. Kuhnert-Brandstatter, et al Mikrochirn. Acta, lOSS (1961) M. Kuhnert-Brandstatter. Thermornicroscopy in the Analysis of Pharmaceuticals, Pergamon Press, New York, 1971 A. T. Florence and E.
7 Blood levels of phenobarbitone versus time after intramuscular injection of three dosage forms. Redrawn from Miller and Fincher, J. pharm. 3 per cent or less, then the dissolution rate in vivo may be the rate-controlling step in absorption 11 • The effect of particle size reduction on dissolution rate is one primarily of exposure of increasing amounts of surface of the drug to the solvent. llll that there is an effect on the intrinsic solubility of the substance (see chapter 5), and thus on its intrinsic dissolution rate.
When the eutectic temperature is reached, however, the remaining solution crystallises out forming a microcrystalline mixture of pure A and pure B, differing markedly at least in superficial characteristics from either of the pure solids. This has obvious pharmaceutical possibilities. This method of obtaining microcrystalline dispersions for administration of drugs was first suggested by Sekiguchi and co-workers 16 ' 1 7 . This involved the administration of a eutectic mixture composed of drug and a substance readily soluble in water.