Download Neuroimmunological Diseases by Susumu Kusunoki PDF

By Susumu Kusunoki

This e-book bargains a close overview of the extraordinary advances which were made in examine at the pathogenesis of a few neuroimmunological ailments, in addition to outlining novel remedies together with using monoclonal antibodies. Written by means of well known specialists who've made significant contributions within the box, corresponding to selecting neuromyelitis optica as an immunopathological medical , picking out the function of ganglioside and ganglioside-complex antibodies in Guillain-Barré syndrome, and constructing a singular remedy for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and epidermis alterations) syndrome, the publication summarizes contemporary advances in easy and medical examine. Neuroimmunological Diseases is an invaluable source for not just researchers but in addition neurologists who're engaged within the administration of neuroimmunological diseases.

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These stimuli also induce a variety of chemokines, nitric oxide (NO), superoxide (Ο2À), and glutamate. TNFα, ΝΟ, and Ο2À have been reported to damage myelin and neuronal cells to induce demyelination and neuronal degeneration. Recently, however, it has been shown that most neurotoxic factor from activated microglia is glutamate, which disturbs mitochondrial respiratory chain to cause energy depletion in neurons [15]. TNFα was a candidate for neurotoxic factor from activated microglia. However, in our experimental conditions, TNFα did not kill neurons.

Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem. 2006;281:21362–8. 17. Horiuchi H, Parajuli B, Wang Y, Azuma Y, Mizuno T, Takeuchi H, Suzumura A. Interleukin19 acts as a negative autocrine regulator of activated microglia. PLoS ONE. 2015;10(3): e0118640. 18. Haines JD, Inglese M, Casaccia P. Axonal damage in multiple sclerosis. Mt Sinai J Med. 2011; 78(2):231–43. 19. Vercellino M, Plano F, Votta B, Mutani R, Giordana MT, Cavalla P.

Effects of colony stimulating factors on isolated microglia in vitro. J Neuroimmunol. 1990;30(2–3):111–20. 35. Zhou Y, Sonobe Y, Akahori T, Jin S, Kawanokuchi J, Noda M, Iwakura Y, Mizuno T, Suzumura A. IL-9 promotes Th17 cell migration into the central nervous system via CC chemokine ligand-20 produced by astrocytes. J Immunol. 2011;187:4415–21. 36. Burkovetskaya M, Karpuk N, Xiong J, Boska M, et al. Evidence for aberrant astrocyte hemichannel activity in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL).

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