By Michael Bauer, Paul Grof, Bruno Muller-Oerlinghausen
The definitive textbook at the use of lithium within the therapy of psychological issues, this entire paintings presents an updated research of lithium, including:
- Clinical functions, together with its use for mania, bipolar and schizophrenic disorders
- Use in distinctive populations, for instance in children, the elderly and individuals with clinical conditions
- The influence at the physique and behaviour, together with neurological, gastrointestinal, cardiovascular and dermatological results, in addition to these in relation to the kidneys and thyroid
- Basic findings in pharmacology, chemistry, delivery within the physique, pharmacokinetics, sign transduction pathways, immune functionality, gene regulation.
- Practical concerns, akin to instructions for secure use, discontinuation matters, compliance, intoxication, and economics.
Edited by means of most sensible specialists from the foreign workforce for the learn of Lithium taken care of sufferers (IGSLi), Lithium in Neuropsychiatry: A complete Guide is a special and important source for psychiatrists, psychopharmacologists, psychotherapists and neuroscientists.
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Extra info for Lithium in Neuropsychiatry: The Comprehensive Guide
It was published in Danish and German, and it has lately been translated into English and supplemented with a biographical portrait of the author8. In this publication Lange gave the first report of his and his brother’s use of a lithiumcontaining mixture for the prevention of recurrences of periodic depressions. Lithium was given in accordance with Lange’s belief in ‘the uric acid diathesis’ – a chimera that nevertheless had an extraordinary resilience. This hypothesis was eventually given up, and lithium treatment was abandoned.
Glesinger B. Evaluation of lithium in treatment of maniacal psychotic excitement. Med J Aust 1954; 1: 277 10. Trautner EM, Morris R, Noack CH, Gershon S. The excretion and retention of ingested lithi- 16. 17. 18. 19. 20. um and its effect on the ionic balance of man. Med J Aust 1955; 2: 42 Gershon S, Trautner EM. The treatment of shock-dependency by pharmacological agents. Med J Aust 1956; 1: 783–7 Trautner EM, Pennycuik PR, Morris RJH, et al. The effects of prolonged sub-toxic lithium ingestion on pregnancy in rats.
It is also interesting to note that Cade’s report appeared in The Medical Journal of Australia, a journal not at everybody’s fingertips in 1949. Thus, it was these uncontrolled observations by an astute clinician on just ten manic patients that produced the platform for the launch of this new era. The same year that Cade published his report, physicians in the USA learned mainly that lithium was a toxic and lethal substance. These cardiac patients were the ideal cases for lithium toxicity, as would be clearly demonstrated in later studies3.