Download Influenza Pathogenesis and Control - Volume I by Richard W. Compans, Michael B. A. Oldstone PDF

By Richard W. Compans, Michael B. A. Oldstone

This two-volume paintings covers the molecular and cellphone biology, genetics and evolution of influenza viruses, the pathogenesis of an infection, resultant host innate and adaptive immune reaction, prevention of an infection via vaccination and techniques to the healing regulate of infection.. specialists on the leading edge of those parts supply severe tests in regards to influenza virology, immunology, phone and molecular biology, and pathogenesis. quantity I presents overviews of the most recent findings on molecular determinants of viral pathogenicity, virus access and telephone tropism, pandemic possibility evaluate, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic edition, whereas quantity II specializes in the function of innate and adaptive immunity in pathogenesis, improvement of vaccines and antivirals.

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02649-08 Stech J, Garn H, Herwig A et al (2011) Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine. J Infect Dis 204:1483–1490. 1093/infdis/jir613 Steinhauer DA (1999) Role of hemagglutinin cleavage for the pathogenicity of influenza virus. Virology 258:1–20. 9716 Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA (2004) Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. Science 303:1866–1870 Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA (2006) Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus.

5 Conclusion and Future Perspectives ................................................................................... References.................................................................................................................................. 36 36 36 37 41 44 46 46 47 48 50 52 53 53 1 Introduction Influenza viruses encode their own RNA-dependent RNA polymerase which consists of three subunits, PB1, PB2 and PA. The viral polymerase complex together with NP mediates transcription and replication of the viral genome in the nucleus of the infected host cell.

PB2 D701N adaptive mutation would facilitate exposure of the NLS. Structures were generated with PyMOL using published PDB accession number 2GMO and RCSB (Tarendeau et al. 2007). Modified from (Gabriel et al. 2013) Molecular Determinants of Pathogenicity in the Polymerase… 41 domain of PA that assumes a ‘‘dragon head’’ shape interacts with the N-terminus of PB1 through its ‘‘jaw’’ (He et al. 2008; Obayashi et al. 2008). NP is an essential component of the influenza virus transcriptional machinery.

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