Download Immunology of Renal Disease by A. Burns, P. Li, A. Rees (auth.), C. D. Pusey (eds.) PDF

By A. Burns, P. Li, A. Rees (auth.), C. D. Pusey (eds.)

Although it's been preferred for a few years that immune tactics underlie so much kinds of glomerulonephritis, it's the contemporary explosion in knowl­ fringe of mobile and molecular immunology that has triggered one other ebook at the topic. the certainty of the mechanisms eager about renal harm calls for the combination of data from in vitro cell-culture platforms, experimental versions of sickness, and medical reports. This quantity attracts on all of those resources in an try and clarify present techniques of nephritis. elevated emphasis is put on autoimmune techniques, in place of the deposition of circulating immune complexes, even though it may be obvious that those may perhaps overlap within the region of "in situ" immune complicated formation. Of principal significance in autoimmunity is the connection among antigen pre­ senting cells (including B cells) expressing MHC category II molecules, autoan­ tigenic peptides, T helper lymphocytes, and diverse effector cells. The mechanisms in which the immune process could lead to tissue damage also are turning into larger understood, and attention is given to the function of inflam­ matory cells, the supplement proteins, and soluble components akin to cytokines and eicosanoids.

Show description

Read or Download Immunology of Renal Disease PDF

Best immunology books

Influenza Pathogenesis and Control - Volume I

This two-volume paintings covers the molecular and telephone biology, genetics and evolution of influenza viruses, the pathogenesis of an infection, resultant host innate and adaptive immune reaction, prevention of an infection via vaccination and techniques to the healing keep watch over of an infection. . specialists on the vanguard of those components offer serious tests in regards to influenza virology, immunology, mobilephone and molecular biology, and pathogenesis.

Therapeutic antibody engineering : current and future advances driving the strongest growth area in the pharmaceutical industry

The sphere of antibody engineering has develop into a necessary and fundamental a part of making new, more desirable subsequent new release healing monoclonal antibodies, of which there are at the moment greater than three hundred in medical trials throughout numerous healing components. healing antibody engineering examines all elements of engineering monoclonal antibodies and analyses the impression that a variety of genetic engineering ways can have on destiny applicants.

Toll-Like Receptors: Practice and Methods

This moment variation quantity expands at the first variation with new advancements on Toll-Like Receptors (TLRs) controlling occasions similar to cross-priming of linked development popularity receptors, post-transcriptional law, interplay with different mobile and biologic structures, and melanoma development.

Immune Rebalancing. The Future of Immunosuppression

Immune Rebalancing: the way forward for Immunosuppression summarizes the main promising views of immunopharmacology, particularly within the sector of immunosuppression by means of contemplating molecular pathways, custom-made medication, microbiome and nanomedicine. Modulation of immune responses for healing reasons is a very appropriate sector, given the crucial position of anomalous immunity in illnesses.

Additional info for Immunology of Renal Disease

Example text

A biphasic autoimmune glomerulonephritis is observed with IgG deposited along the GBM in a linear pattern during the first phase, from day 859 . Later (from the third week) a typical membranous glomerulonephritis is superadded 60 . The mechanism of formation of subepithelial deposits is still unknown; however, Ig eluted from kidneys with predominantly granular deposits binds in a linear pattern when incubated on normal kidney cryostat sections 60 . Several non-exclusive hypotheses may be proposed to explain the formation of granular deposits, including deposition of circulating GBM-antiGBM immune complexes or rearrangement of linear IgG deposits due to the deposition of anti-idiotypic antibodies.

And Wraith, D. C. (1988). Limited heterogeneity ofT cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell, 54, 263-273. 22. Urban, 1. , Kono, D. , Horvath, S. , Ando, D. , Sercarz, E. and Hooc, L. (1988). Restricted use of T cell receptor V genes in murine 23 IMMUNOLOGY OF RENAL DISEASES autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell, 54, 577-592. 23. Burns, F. , Chou, Y. , Vandenbark, K. and Heber-Katz, E.

D. (1985). DNA polymorphism of the C2 and factor B genes. Immunogenetics, 21, 39-48. 29. Alper, C. , Awdeh, Z. L. and Yunis, E. J. (1983). Serum complement 'Supergenes' of the major histocompatibility complex in man (complotypes). Vox. , 45,62-67. 30. Awdeh, Z. , Yunis, E. J. and Alper, C. A. (1983). Extended HLA/complement allele haplotypes: evidence for Tit like complex in man. Proc. N atl. Acad. Sci USA, SO, 259-263. 31. Connealy, P. M. and Rivas, M. L. (1980). Linkage analysis in man. Adv. Hum.

Download PDF sample

Rated 4.44 of 5 – based on 19 votes