By T. Honjo, F. W. Alt
The immunoglobulin gene complicated is liable for producing an awfully wide selection of antibodies, each one owning a special antigen specificity. the second one variation of Immunoglobulin Genes brings the reader brand new with the speedy development in our figuring out of the program. Firmly proven because the definitive e-book at the subject, it presents an absolutely entire account of the association, functionality, rearrangement and expression of those and similar genes. because the e-book of the 1st variation, the paintings has been generally revised and up to date to hide new learn information on human immunoglobulin genes in addition to mammalian and reduce vertebrate structures. New chapters contain "Somatic mutation and B mobilephone Maturation", "Antigen receptors" and "B lymphocyte tolerance within the mouse."For the immunologist, there are specified descriptions of the molecular mechanisms which generate this assorted diversity of antibodies and the tight legislation of the genes encoding them. Molecular biologists will locate discussions of vital phenomena together with gene rearrangement, differential splicing and deletion within the context of immunoglobulin genes.The pleasure of analysis on immunoglobulin genes is conveyed through the variety and complexity of concerns mentioned right here; the e-book comprises precious details for clinicians and learn scientists with an curiosity within the immune reaction. * Conveys the thrill of study on immunoglobulin genes through the variety and complexity of matters* includes useful info for clinicians and examine scientists with an curiosity within the immune reaction* For the Immunologist* specified descriptions of the molecular mechanisms producing this different diversity of antibodies and the rules of genes encoding them* For the Molecular Biologist* Discusses vital phenomena together with gene rearrangement, differential splicing, and deletion within the context of immunoglobulin genes.
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Extra info for Immunoglobulin Genes
It belongs to a family of metallopeptidases that are widely distributed in many tissues, but which display lineage and differentiation stage-specific expression among hemopoietic cells (Shipp and Look, 1993). , 1990). These ectoenzymes may activate or inactivate biologically active peptides that can modulate hemopoietic cell development or function. Among the known substrates of CD10 are the enkephalins, bradykinin, oxytocin, substance P, and fMet-Leu-Phe, but whether these are biologically relevant to B cell development is unknown.
1992, 1993) have demonstrated that inhibition of CD 10 enzymatic activity enhances murine B cell development in vitro and in vivo, suggesting that CD 10 may inactivate a peptide growth factor. CD 10 is B-ceU differentiation in humans 13 expressed on early precursors of both B and T cells and some bone marrow stromal cells, as well as the brush border epithelium of kidney and intestine. CD10 is not expressed on peripheral B cells, except for germinal center centroblasts and centrocytes. This is an interesting exception, since it appears that lymphoid cells that express CD10 are engaged in modification of their antigen receptor genes; thus CD10 § pre-B and pre-T cells are undergoing V(D)J rearrangement and somatic mutation and isotype switching are occurring in germinal center B cells.
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