By Abraham L Kierszenbaum M.D. Ph.D., Laura Tres M.D. Ph.D.
Totally integrating histology, telephone biology, and pathology, the 4th variation of the award-winning Histology and telephone Biology: An advent to Pathology provides key ideas in an comprehensible, easy-to-digest demeanour. Authors Abraham L. Kierszenbaum, MD, PhD and Laura L. Tres MD, PhD hyperlink uncomplicated technological know-how to scientific program all through, targeting what you want to understand to your coursework now - and the way to apply that details in a medical environment . Full-color illustrations on each web page, in addition to particular, student-friendly beneficial properties on-line, assist you speedy take hold of the complexities of pathologic abnormalities. �Read more...
summary: totally integrating histology, mobilephone biology, and pathology, the 4th variation of the award-winning Histology and mobile Biology: An advent to Pathology provides key techniques in an comprehensible, easy-to-digest demeanour. Authors Abraham L. Kierszenbaum, MD, PhD and Laura L. Tres MD, PhD hyperlink easy technological know-how to medical program all through, concentrating on what you must be aware of on your coursework now - and the way to use that info in a scientific surroundings . Full-color illustrations on each web page, in addition to particular, student-friendly positive factors on-line, assist you fast take hold of the complexities of pathologic abnormalities
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Additional resources for Histology and Cell Biology: An Introduction to Pathology, 4e
ICAM-1 and VCAM-1 bind to `2 and `1 integrin subunits in leukocytes (see Figure 1-12). 6. The cohesive nature of the epithelium depends on three factors: cell junctions, cell adhesive molecules and the interaction of integrins with the extracellular matrix, produced to a large extent by ﬁbroblasts. 7. The basal lamina is essential for the differentiation of epithelial cells during embryogenesis. Note in Figure 1-23 that: 1. The basal domain of epithelial cells interacts with the basal lamina through hemidesmosomes and integrins.
The macula adherens or spot desmosome 3. The hemidesmosome Zonula adherens or belt desmosome Similar to the tight junctions, the zonula adherens is a beltlike junction. The zonula adherens (Figure 1-16) is associated with actin microﬁlaments. This association is mediated by the interaction of cadherins (desmocollins and desmogleins) with catenins (_` and p120). The main desmogleins expressed in the epidermis of the skin are desmoglein 1 and desmoglein 3 (Figure 1-17). Macula adherens or spot desmosome Anchoring junctions Anchoring junctions are found below the tight junctions, usually near the apical surface of an epithelium.
Gap junctions are not anchoring junctions. Instead, gap junctions are communicating junctions connecting adjacent cells. The basic unit of a gap junction is the connexon, formed by 6 connexin molecules encircling a central channel. 18 1. EPITHELIUM Cell junctions Figure 1-23 presents the highlights of cell adhesion molecules and cell junctions. 1. An epithelium is a continuous sheet of polarized cells supported by a basement membrane. 2. The polarized nature of an epithelium depends on the tight junctions that separate the polarized cells into apical and basolateral regions.