Download Current Topics in Bioenergetics, Volume 17: Molecular Basis by Author Unknown PDF

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The sphere of mitochondrial illnesses is at present one of many speedily growing to be fields of study in telephone and molecular biology. This quantity encompasses the most recent improvement during this box of analysis. The chapters hide issues in a variety of disciplines together with biophysics, biochemistry, cellphone and molecular biology, molecular genetics, and scientific drugs.

Summarizes turning out to be facts of the function of mitochondria in loads of pathological conditions
Brings jointly assorted techniques towards realizing mitochondria diseases
Molecular and mobile biology
Clinical body structure and medicine
Details the the most important function this organelle performs in genetic legislation of varied organic capabilities.

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Extra info for Current Topics in Bioenergetics, Volume 17: Molecular Basis of Mitochondrial Pathology

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Kim and T. ), pp. 413-427. Plenum, New York. , and Mizuno, Y. (1990b). Biochem. Biophys. Res. Commun. 172, 483-489. , and Yoneda, M. (1991). Prog. Neuropathol. 7, 141-151. Parker, W. , Boyson, S. , Luder, A. , and Parks, J. K. (1990a) Neurology 40, 12311234. Parker, W. , Filley, C. , and Parks, J. K. (1990b). Neurology 40, 1302-1303. , and Matsumoto, L. (1977). Nucleic Acids Res. 4, 1301-1314. , Hougham, A. , and Bulpitt, K. J. (1988). Mech. Ageing Dev. 43, 279-293. , Deadman, M. , Turnbull, D.

1990). Mutat. Res. 237, 1-8. , and Horai, S. (1988). Biochem. Biophys. Res. Commun. 154, 1240-1247. , and Sahashi, K. (1990a). In "Bioenergetics" (C. H. Kim and T. ), pp. 413-427. Plenum, New York. , and Mizuno, Y. (1990b). Biochem. Biophys. Res. Commun. 172, 483-489. , and Yoneda, M. (1991). Prog. Neuropathol. 7, 141-151. Parker, W. , Boyson, S. , Luder, A. , and Parks, J. K. (1990a) Neurology 40, 12311234. Parker, W. , Filley, C. , and Parks, J. K. (1990b). Neurology 40, 1302-1303. , and Matsumoto, L.

Polarographic analysis showed decreased respiration with both NAD-dependent substrates and succinate, but cytochrome spectra were normal. Clinically, both sisters had normal early milestones, but developed exercise intolerance and slowly progressive weakness of axial and proximal limb muscles, sparing facial and extraocular muscles. Around age 5, brain involvement was manifested by learning disability in both sisters, seizures in one, and cerebellar syndrome in the other. 4. Defects of Complex IV Complex IV, or cytochrome c oxidase (COX), the last enzyme complex of the respiratory chain, catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen.

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