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24 Dry Eyes will tell you how to obtain this information later in the chapter. , New York, NY 10471) Assignee(s): none reported Patent Number: 5,041,434 Date filed: May 7, 1990 Abstract: A topical drug application for the alleviation of keratoconjunctivitis sicca (dry eye syndrome) is comprised of a solution of sex steroids or their derivatives suspended or dissolved in a vehicle, and the method of preparation and application of the same. In the preferred embodiments, the sex steroid consists essentially of conjugated estrogen in a lipid vehicle or a derivative of estrogen known as 17 beta-Estradiol 3-phosphate disodium dissolved in an aqueous vehicle having a pH of between 6 and 8.

As patients with SS usually emphasize subjective symptoms, the authors mention a few key features. The four most troublesome symptoms (in order of frequency at the time of diagnosis) are extraordinary tiredness, dry mouth, dry eyes, and pain in the wrist or finger joints. The authors conclude that the routinely used clinical tests for evaluating disease activity probably measure both activity and damage. No immunopathogenic markers have been shown to adequately represent all aspects of disease activity to date.

Org. 00 for nonmembers; plus shipping and handling. ISBN: 0195117247. Summary: This book offers a comprehensive guide to Sjogren's syndrome (SS). Designed both for people with Sjogren's and for physicians, the 26 chapters provide readers with both medical and practical information on this disorder. The book describes the symptoms, which can range from dry eyes and dry mouth (xerostomia), to hoarseness and difficulty in eating, to chronic fatigue and joint pain that can seriously impair quality of life.

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