By Thomas R. Kosten, Thomas F. Newton, Richard De La Garza II, Colin N. Haile
Cocaine and Methamphetamine Dependence: Advances in therapy presents a entire precis of what psychiatrists and citizens want to know approximately stimulant dependence and its remedy on the way to circulation past the fundamentals of this advanced ailment. Ever-clearer proof indicates stimulant dependence should be thought of a mind sickness. certainly, neuroimaging stories point out stimulant dependence might be received via epigenetic activation of a preexisting vulnerability particularly genes starting up possibilities to right the underlying neurochemical abnormalities on the genetic point. remedies for stimulant dependence are speedily evolving, and this quantity specializes in empirically verified remedies combining drugs with habit treatment. moreover, the authors document on a up to date shift to extra humane responses in the felony justice method that has turn into an important in acquiring remedy for the anticipated 1.6 million cocaine and half-million methamphetamine clients who abuse those medicinal drugs on a daily basis. present, centred assurance of those and different key remedy issues, comparable to HIV comorbidity and polydrug abuse, make this publication crucial examining for psychological health and wellbeing clinicians
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Additional info for Cocaine and methamphetamine dependence : advances in treatment
Recognizing that this dangerous drug cannot be controlled, and that harsh penalties have not adequately deterred use, the recent emphasis on harm reduction and medical treatment may offer a better alternative to addressing the problem of drug dependence in general, and cocaine dependence in particular (Greenwald 2009; Mancini and Linhorst 2010). “Über Coca”: A Brief History of Cocaine Cocaine was first extracted from the leaves of the coca plant (Erythroxylon coca) (Figure 2–7A) by Gaedcke in 1855.
That is, plasma concentrations of cocaine are directly correlated to its physiological and subjective effects (Javaid et al. 1978; Newton et al. 2005a). The rapidity with which the freebase formulation enters systemic circulation is a key element to cocaine’s addictive potency. This feature is consistent with findings from human imaging studies, which demonstrated that the more quickly an addictive drug enters systemic circulation, the faster it crosses the blood-brain barrier, and the higher the abuse liability (Fowler et al.
Under certain circumstances, stimulants such as cocaine and METH can induce sensitization. That is, a drug dose can produce greater behavioral effects upon multiple exposures over time. Like cross-tolerance, cross-sensitization can occur between drugs in the same class. History, Use, and Basic Pharmacology of Stimulants TABLE 2–1. 15 Important definitions Substance abuse Use of a substance has led to impairment or distress that may include failure to meet work, school, or home obligations; use during hazardous activities; recurrent substance-related legal issues; and continued use despite obvious problems.