Download Cancer Immunotherapy Volume 90 by James Allison, Glen Dranoff PDF

By James Allison, Glen Dranoff

For it slow immunotherapy has been heralded as a step forward process for melanoma therapy. even though the potential for this method continues to be good, the strategy wishes substantial refinement. when a few programmes want to raise the certainty of molecular and mobile mechanisms underlying the stimulation of antitumor immunity, others are looking for the main applicable medical environment that would demonstrate the position of the immune method in fighting melanoma. one of the most vital discoveries were tumor-specific antigens. This thematic quantity highlights a few key concerns and discusses the place they might circulate ahead. it's been prepare via major melanoma immunotherapists from eminent associations that concentrate on melanoma examine.

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2002, 2004a,b). 1. Equilibrium Although the elimination phase of the cancer immunoediting process can eradicate a significant percentage of transformed cells, there can exist a period of latency extending from the end of the elimination phase to the beginning of the escape phase and the emergence of clinically detectable malignant disease. This potentially protracted period in the course of the immune system/tumor interaction that occurs prior to the detection of clinically apparent tumors C A N C ER I M M U N O S U RV E I L L A N C E / I MM U N O ED I T I N G 29 constitutes the equilibrium phase.

2002, 2004b). , colon, lung, bladder, pancreas, kidney, ureter carcinomas, melanomas, squamous cell carcinoma, and endocrine tumors). Thus, individuals with normal immune systems who undergo immunosuppression display an increased probability of developing a variety of cancers that have not been linked to a viral etiology. This observation may indicate that immunosuppressive intervention predisposed the transplant patients either to de novo tumor formation or allowed the outgrowth of occult tumors whose growth was contained by a functioning immune system and were thus held in a state of durable equilibrium.

2001). , 1989). Overall, TNF has a dual role in cancer, inducing destruction of blood vessels and cell‐mediated killing of certain tumors, as well as acting as a tumor promoter. , 1999). Expression studies have confirmed high concentrations of TNF in tumors and associations between single nucleotide polymorphisms (SNPs) in 28 MARK J. SMYTH ET AL. the TNF gene and a variety of cancers exist [reviewed in (Szlosarek and Balkwill, 2003)]. Its role in cancer progression has stimulated interest in the use of TNF antagonists for the prevention and treatment of cancer.

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