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By Geoffrey H. Bourne

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Wuthier (1971b), by means of quantitative analyses of acidic phospholipids, also offered a rational explanation for the original histological observation by Irving (loc cit, 1973b) on the disappearance of the Sudanophilic line from the epiphyseal cartilage in rickets. The extractability of the acidic phospholipids was inversely proportional to the level of the mineral in matched pairs of the normal and rachitic calcified cartilage. , calcium phosphate and protein. The acidic phospholipids may also stabilize amorphous calcium phosphate and block the phosphate conversion of noncrystalline calcium phosphates to apatite.

Compounds with Ρ—C—Ρ bonds have some biological effects that are the same as those of inorganic 1. Biochemistry of Calcification 41 pyrophosphate and condensed polyphosphates and are also being surveyed for use in treatment of diseases of pathological calcification in human beings. X. Extraskeletal Calcification Five important clues for a solution to the problem of calcification are derived from observations on extraskeletal calcification. The first is that the proteinaceous structure of every organ and tissue can be converted into calcifiable matrix and is known to calcify under pathological conditions.

1973) report that three different diphosphonates inhibit inorganic alkaline pyrophosphatase activity of calcifying hamster molars. The mechanism of inhibition may be attributable to complex formation with a bivalent cation other than magnesium, the cofactor for the enzyme; hence, in vivo diphosphonate, in addition to inhibiting apatite crystal formation directly, may inhibit mineralization by suppressing inorganic pyrophosphatase activity. , 1. Biochemistry of Calcification 31 protein polysaccharide-bound calcium, proteolytic enzyme activity, and acid phospholipid (Wuthier, et al, 1972).

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