Download Brain Tumors: Pathology and its Biological Correlates by Davide Schiffer PDF

By Davide Schiffer

The aim and objective of this paintings it to provide the pathology of mind tumors interpreted via its organic correlates. in addition, larger knowing of the various oncological and neuropathological difficulties of mind tumors in addition to higher figuring out of neuro-imaging prognostic difficulties.

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630]. In a series of 93 cases during the first 18 months of life in the UK, the most frequent tumors were medulloblastoma, ependymoma and astrocytoma. Only one teratoma was found [1530]. 4 Risk Factors: Epidemiological Data The source of data relating to risk factors for cerebral tumors in man is twofold: descriptive clinicopathological studies and epidemiological studies. ), while the latter (more often case-control studies) have tried to confirm the significance ofthe associations previously suggested and to identify others which are still unknown.

These changes, represented by translocations onto 17p or chromosome 17 loss, were different from abnormalities usually detected in astrocytomas and medulloblastomas (isochromosome 17q). Chromosomal abnormalities found in medulloblastomas are different from those described in malignant gliomas. Structural changes, such as isochromosome 17q (resulting in loss of one copy of 17p), translocations (8; 11), unbalanced translocations of 20q13, and deletions of 6q, 11, and 16q are more common than gain or losses of whole chromosomes [212, 1005,365].

The blood group A has been found to be positively associated with intracranial tumors in males [315] and with gliomas in general [2592], and blood group 0 with hypophyseal tumors [1830]. By contrast, some authors deny the importance of blood groups [879,437]. Religious affiliation and tonsillectomy are not important [955, 330]. Patients who are immunosuppressed because of renal transplants have a 350-fold greater risk than controls of developing lymphoma, many of which are cerebral [1176]. Various diseases have been reported to be associated with CNS tumors, but for none of these has a thread of significance emerged.

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