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By William T. Jackson, Michele Swanson

Autophagy, an infection, and the Immune Response provides a unified assessment of the jobs of mobile autophagy in the course of microbial infection.

Introductory chapters ground the reader through laying out the autophagic pathway from a mobile perspective, and directory assays on hand for measuring autophagy. next chapters address virus interactions with autophagy equipment, some of the roles of autophagy parasitic an infection, and interactions of micro organism with the autophagic pathway. Concluding chapters explore the relationships of autophagy to systemic immune responses, together with antigen presentation, ER rigidity, and creation of IFN-gamma.

Designed as a source for these attracted to starting up studies on the connection among autophagy and an infection or immunity, the book combines sensible state-of the artwork strategy descriptions with an summary of the big variety of identified interactions among pathogens and the autophagic pathway.

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2005) Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc. Natl Acad. Sci. USA 102, 7922–7927. , and Levine, B. (2009) Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5, 527–549. F. (2007) Chaperone-mediated autophagy. Autophagy 3, 295–299. , and Brossart, P. (2005) Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA. Blood 105, 3199–3205. , et al. (2009) Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection.

Autophagy 7, 336–337. , et al. (2010) Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity 32, 329–341. , and Levine, B. (2007) Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 128, 931–946. C. (2002) Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11, 1107–1117. J. (2004) The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure.

Autophagy is not only involved in innate immune responses but also plays a role in adaptive immunity by promoting microbial antigen processing and MHC–antigen presentation to T cells. Moreover, autophagy is relevant to inflammation and autoimmune diseases. A better understanding of the molecular mechanisms that underlie autophagy and immune signaling pathways may facilitate insights into many infectious, inflammation, and autoimmune diseases and ultimately promote the discovery of novel therapeutic targets for clinical treatment of these diseases.

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