Download Attrition in the pharmaceutical industry : reasons, by Alexander Alex, C. John Harris, Dennis A. Smith PDF

By Alexander Alex, C. John Harris, Dennis A. Smith

With a spotlight on case stories of R&D courses in quite a few illness parts, the e-book highlights basic productiveness concerns the pharmaceutical has been dealing with and explores power methods of enhancing learn effectiveness and efficiency.

• Takes a complete and holistic method of the issues and power recommendations to drug compound attrition
• Tackles an issue that provides billions of greenbacks to drug improvement courses and healthiness care costs
• Guides discovery and improvement scientists via R&D levels, educating specifications and explanation why medicinal drugs can fail
• Discusses strength methods ahead using new techniques and possibilities to minimize attrition

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Extra info for Attrition in the pharmaceutical industry : reasons, implications, and pathways forward

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The combination of amoxicillin and the β-lactamase inhibitor clavulanic acid has been a longtime success for the treatment of penicillin‐resistant bacteria. The fixed‐dose combinations of a β2 ago­ nist and a steroid, such as Symbicort (budesonide and formoterol) and Advair ­(fluticasone and salmeterol), are world’s leading therapies for asthma and COPD. Gilead in combination with various pharmaceutical partners has a portfolio of fixed‐dose combina­ tions for HIV/AIDS treatment including Stribild, approved in 2012, a quad combination of elvitegravir/cobicistat/emtricitabine/tenofovir; Complera, a triple combination of ­rilpivirine + e­mtricitabine + tenofovir approved in 2011; as well as Atripla, a triple combination of efavirenz + emtricitabine + tenofovir approved in 2006, and Truvada, a double combination of emtricitabine + tenofovir approved in 2004.

In December 2013, the Dementia Consortium launched a £3M fund to bolster dementia drug discovery. 1B of research in the United Kingdom alone. In 2012, the Bill and Melinda Gates Foundation alone made grants of $892M for global health projects. To stimulate R&D into new anti‐infectives, and following a European Parliament resolution to establish an European Union‐wide plan to combat antimicrobial resistance, the Innovative Medicines Initiative in partnership with five pharmaceutical companies has launched a $280M program to spur new anti‐infective R&D [59] and will fund a phase III program for GSK’s peptide formylase inhibitor for community‐acquired pneumonia.

However, its label was amended in 2001, as concerns surfaced over hepatic risks and its cardiovascular safety when used in combination therapy with insulin compared to insulin therapy alone [41]. In 2001, along with the label change, the FDA also requested GSK embark on the 6‐year “RECORD” study comparing cardiovascular outcomes of Avandia to other commonly prescribed antidiabetic drugs. Meanwhile, in 2004, in a settlement after a lawsuit concerning the withholding of ­negative clinical trial data on another of GSK’s drugs, Paxil, the company agreed to pub­ lish all its clinical trial data on its own website.

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