By Ronald Marks, Arthur Knight, P. Laidler (auth.)
Dermatopathology is either intriguing and exasperating. tum corneum cells. this happens in issues of keratiniza epidermis has a chic simplicity in its services but a tion as the technique of desquamation is disturbed (Figure 1. 1). ferocious complexity in its constitution. this is often one of many paradoxes that underly the pathology of dermis affliction Parakeratosis. The presence of nucleated horn cells in and will pass a way in explaining the multitudinous the stratum corneum. typically the horn cells (corneocy problems to which the outside is topic. The prepared visibility tes) are skinny lamellae of lower than 1 f. lm thickness. They of the surface can assist clarify why user-friendly comprise no detectable cytoplasmic contents as those are histological exam can't continuously offer an misplaced within the granular telephone layer. Parakeratosis happens while solution to a clinicians's query. particularly dramatic seem the method of keratinization is disturbed reminiscent of while ances might be because of changes of the relative charges of the speed of epidermal cellphone construction is elevated (as in blood movement, without or with oedema, within the various psoriasis) in order that nuclei will not be damaged down prior to the vascular plexuses or round various buildings within the stratum corneum is reached and while harm happens horizontal size, neither of which can bring about to the higher skin (Figure 1. 2). 'much to work out' histologically. The inherent sampling errors Porokeratosis.
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Plaques and tumours. Histopathology. A tuberculoid granuloma is frequently seen in cutaneous tertiary syphilis. Differentiation may be possible by noting several points. The lupus vulgaris granuloma is higher in the dermis and more organized in appearance than that of tertiary syphilis. Plasma cells are rare in lupus vulgaris and common in syphilis. Necrosis is not seen commonly in lupus vulgaris but is present in syphilis. Fibrosis is a constant feature in tertiary syphilisand is best demonstrated by absence of elastic fibres in and around the granuloma.
Pathologic findings in human scabies. Arch. Oermatol.. 113. 320 Disorders of Keratinization 4 Epidermolytic Hyperkeratosis (also known as bullous ichthyosiform erythroderma) This is a rare dominantly inherited disorder in which there is generalized scaling and hyperkeratosis as well as a background of erythema. In addition there is a tendency to blistering with trauma that seems to improve with age. Even more rarely the disorder only occurs at localized sites either as a form of verrucous naevus or as a type of palmoplantar keratoderma 6 .
9). e. the basal layer, may show irregular villous-like hypertrophy. 10). Ultrastructurally the cells show abnormalities of the tonofilament desmosomal plate complex 9 . Unlike pemphigus there are no characteristic immunofluorescent findings. For differential diagnosis of suprabasilar clefting, see Chapter 5. Chronic Benign Familial Pemphigus (Hailey-Hailey disease) This uncommon disorder has some similarity to Darier's disease but is considered in Chapter 5. References 1. Dykes, P. J. and Marks, R.