Download Artificial Immune Systems: 4th International Conference, by Peter J. Bentley, Gordana Novakovic, Anthony Ruto (auth.), PDF

By Peter J. Bentley, Gordana Novakovic, Anthony Ruto (auth.), Christian Jacob, Marcin L. Pilat, Peter J. Bentley, Jonathan I. Timmis (eds.)

This ebook constitutes the refereed complaints of the 4th foreign convention on man made Immune structures, ICARIS 2005, held in Banff, Alberta, Canada, in August 2005.

The 37 revised complete papers awarded have been conscientiously reviewed and chosen from sixty eight submissions. The papers are equipped in topical sections on conceptual, formal, and theoretical frameworks, immunoinformatics, theoretical and experimental stories on man made immune structures, and purposes of synthetic immune systems.

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Extra info for Artificial Immune Systems: 4th International Conference, ICARIS 2005, Banff, Alberta, Canada, August 14-17, 2005. Proceedings

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Antigen Dynamics. Antigens can be added at any iteration of the algorithm, either as a “batch” in which a number of antigens are added simultaneously at some iteration x, or individually. Each newly-created antigen has a experimentally pre-specified concentration. At each cycle, the total affinity Aa of an antigen A at (x, y) is computed in a somewhat similar way by looking at the cells in the complementary region S centered at the complementary point B = (X − x, Y − y): Ec (r − ||E − B||) Aa = cells E∈S If Aa ≤ L the concentration of A is unaffected, but if Ac > L then the concentration decreases by an amount Ac /(100L).

2 Exogenous Antigens with Low Concentration Figure 6 shows the results of identical experiments to those above but when the concentration of added antigen is reduced to 100. Comparing the figures to those just presented shows that the concentration of antigens clearly plays a large part in the behaviour of the system. Firstly, without a network, the behaviour obtained by the circular and cross regions is exactly comparable to Bersini’s results obtained in Hamming space across all values of R. When compared to those results obtained when Ac = 1000, comparable behaviour is observed until approximately R = 75 (circle) and R = 65 (cross).

Qualitatively, the observed differences can be explained by comparing the area of the recognition regions for equivalent radii in the two systems. For example, a value of R = 1 for the circle space gives an area of π. In the cross-space, the area of the region is 20, therefore, there is much higher probability of being able to match antigen. For the box region, for the reasons outlined in section 6, the system is able to tolerate antigens over a wide variation in R, because a high-value of R effectively results in a very low match-probability.

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