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New York: Wiley Moore W, Kautz R. 1986. Data analysis for flow cytometry. In The Handbook of Experimental Immunology, ed. LA Herzenberg, DM Weir, CC Blackwell, LA Herzenberg. Edinburgh: Blackwell Scientific, pp. 30–36 Herzenberg LA, Ledbetter JA. 1979. Monoclonal antibodies and the fluorescenceactivated cell sorter: complementary tools in lymphoid cell biology. In Molecular Basis of Immune Cell Function, pp. 315– 30. Amsterdam: Elsevier/North-Holland Biomedical Jones PP, Cebra JJ, Herzenberg LA.

30:841–56 Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, et al. 1997. Glutathione deficiency is associated with impaired survival in HIV disease. Proc. Natl. Acad. Sci. USA 94:1967–72 Ghezzi P, Romines B, Fratelli M, Eberini I, Gianazza E, et al. 2002. sgm LaTeX2e(2002/01/18) TWO LIVES INTERTWINED Annu. Rev. Immunol. 22:1-31. org by HINARI on 09/01/07. For personal use only. of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection. Mol. Immunol.

However, each C-type lectin may recognize a unique branching and positioning of mannose residues on a given pathogen or self-antigen structure (19, 21, 27, 40–44). Also, multimerization of the receptor influences carbohydrate specificity (42). For example, the neck domain of DC-SIGN consists of 7 repetitive sequences that are thought to effect oligomer formation. The oligomerization of lectin domains alters the affinity and specificity of carbohydrate recognition (45). Strikingly, MR and MGL-1 form trimers, whereas DC-SIGN has been shown to form tetramers (42), which may partly explain the differences in carbohydrate specificity (38).

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