Download Analogue-based Drug Discovery by Janos Fischer, C. Robin Ganellin, David P. Rotella PDF

By Janos Fischer, C. Robin Ganellin, David P. Rotella

The 1st authoritative evaluate of previous and present suggestions for winning drug improvement by way of analog iteration, this particular source spans all very important drug periods and all significant healing fields, together with histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds.Of the nineteen analog periods provided intimately, nine are defined via the scientists who discoverd them.The ebook encompasses a desk of the main profitable drug analogs as in line with the IMS rating and compares them when it comes to chemical constitution, mode of motion and patentability.

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In addition, most of these satisfy Lipinski’s [44], Veber’s [45], Bergström’s [46], and Wenlock’s [47] observations in terms of solubility, oral bioavailability, and drug-likeness. Patentability When a well-known drug hits with a new target, there is a risk that several hundreds or thousands of analogues of the original drug molecule are already synthesized by the original inventors and their competitors. These molecules are usually protected by patents, or already belong to the public domain. Thus, at a first glance, a high risk of interference appears probable.

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