By Maria M. Picken MD PhD FASN, Ahmet Dogan, Guillermo A. Herrera
The moment version of this article provides an summary of the latest advancements during this sector together with scientific presentation, etiology, pathogenesis, and differential analysis. the explanation for varied remedies, together with transplantation, is mentioned and tissue analysis (its pitfalls and techniques for averting them) and laboratory help are incorporated. The involvement of all significant organ platforms together with renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central apprehensive procedure, gentle tissue, pores and skin, lymph node/spleen and bone marrow pathology is additionally covered.
Amyloid and comparable issues, moment Edition should be helpful to really expert and normal pathologists in addition to cytopathologists. different doctors can also take advantage of this concise replace at the systemic amyloidoses.
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Additional resources for Amyloid and Related Disorders: Surgical Pathology and Clinical Correlations
Besides mature bone marrow plasma cells, the amyloidogenic clone also includes more undifferentiated bone marrow progenitors as well as mature B lymphocytes and plasma cells in peripheral blood [91–94]. Clonal plasma cell elements can also be found in the spleen and might serve as a source of amyloidogenic light chains . Exposure to certain cytokines leads to in vitro differentiation of peripheral clonal elements into plasma cells that are very similar to their bone marrow counterparts .
51. Makin OS, Atkins E, Sikorski P, Johansson J, Serpell LC. Molecular basis for amyloid ﬁbril formation and stability. Proc Natl Acad Sci USA. 2005;102:315–20. 52. Nelson R, et al. Structure of the cross-beta spine of amyloid-like ﬁbrils. Nature. 2005;435:773–8. 53. Greenwald J, Riek R. Biology of amyloid: structure, function, and regulation. Structure. 2010;18: 1244–60. 54. Sawaya MR, et al. Atomic structures of amyloid cross-beta spines reveal varied steric zippers. Nature. 2007;447:453–7. 55.
9) The anthracycline 4′-iodo-4′-deoxydoxorubicin (IDOX) interferes with amyloid ﬁbril growth and promotes amyloid clearance References 7. 1. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003;349:583–96. 2. Carrell RW, Lomas DA. Conformational disease. Lancet. 1997;350:134–8. 3. Knowles TP, Vendruscolo M, Dobson CM. The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol. 2014;15:384–96. 4. Fandrich M, Fletcher MA, Dobson CM. Amyloid ﬁbrils from muscle myoglobin.