Download A Handbook for DNA-Encoded Chemistry: Theory and by Robert A. Goodnow Jr. PDF

By Robert A. Goodnow Jr.

This booklet comprehensively describes the improvement and perform of DNA-encoded library synthesis expertise. jointly, the chapters aspect an method of drug discovery that provides an enticing addition to the portfolio of latest hit iteration applied sciences resembling high-throughput screening, structure-based drug discovery and fragment-based screening. The book:

  • Provides a invaluable consultant for knowing and using DNA-encoded combinatorial chemistry
  • Helps chemists generate and reveal novel chemical libraries of huge dimension and caliber
  • Bridges interdisciplinary parts of DNA-encoded combinatorial chemistry – man made and analytical chemistry, molecular biology, informatics, and biochemistry
  • Shows medicinal and pharmaceutical chemists easy methods to successfully increase on hand “chemical house” for drug discovery
  • Provides specialist and updated precis of stated literature for DNA-encoded and DNA-directed chemistry expertise and methods

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Additional resources for A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery

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Rev. , 11, 31–46. 18 Just Enough Knowledge… 25. , Syed, B. A. (2013). Commercial prospects for genomic sequencing technologies. Nat. Rev. , 12, 341–342. 26. , Mermod, J. , Kawashima, E. (2000). Solid phase DNA amplification: characterization of primer attachment and amplification mechanism. , 28, e87. 27. , Turcatti, G. (2006). BTA, a novel reagent for DNA attachment on glass and efficient generation of solid-phase amplified DNA colonies. , 34, e22. 28. , Kim, D. , Marma, M. , Edwards, J. , Turro, N.

DNA molecules have a net negative charge due to the negatively charged phosphate groups of the backbone. This charge enables them to migrate through an inert gel matrix when an electric field is applied across the gel. The rate of migration of charged molecules in electrophoresis is known as electrophoretic mobility. Molecules differing in size move through the pores of the gel with different rates. Smaller DNA fragments migrate faster than larger ones forming a distinct band pattern on the gel.

The replication is initiated by helicase that unzips the two strands of the double helix creating the replication fork. Proteins known as single-stranded DNA-binding proteins bind to freshly unwound single strands, preventing them from annealing and protecting them from digestion by nucleases. DNA polymerases polymerize nucleotide triphosphates complementary to the template strands. When the polymerase “sees” guanine on the parent strand, it will add cytosine nucleotide to the new strand in the complementary position, and in the case of adenine being on the parent strand, it will add a thymine nucleotide.

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